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Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 627-636 doi: 10.1007/s11684-020-0815-4
Keywords: RUNX1 gene mutation acute myeloid leukemia transcriptional repression DNA methylation
Development of a dual temperature control system for isoprene biosynthesis in
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 7, Pages 1079-1089 doi: 10.1007/s11705-021-2088-0
Keywords: transcriptional activator directed evolution dynamic control heat-shock isoprene
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu
Frontiers of Medicine 2016, Volume 10, Issue 2, Pages 183-190 doi: 10.1007/s11684-016-0440-4
We performed weighted gene coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellular carcinoma (HCC). Raw microarray datasets (including 488 samples) were downloaded from the Gene Expression Omnibus (GEO) website. Data were normalized using the RMA algorithm. We utilized the WGCNA to identify the coexpressed genes (modules) after non-specific filtering. Correlation and survival analyses were conducted using the modules, and gene ontology (GO) enrichment was applied to explore the possible mechanisms. Eight distinct modules were identified by the WGCNA. Pink and red modules were associated with liver function, whereas turquoise and black modules were inversely correlated with tumor staging. Poor outcomes were found in the low expression group in the turquoise module and in the high expression group in the red module. In addition, GO enrichment analysis suggested that inflammation, immune, virus-related, and interferon-mediated pathways were enriched in the turquoise module. Several potential biomarkers, such as cyclin-dependent kinase 1 (CDK1), topoisomerase 2α (TOP2A), and serpin peptidase inhibitor clade C (antithrombin) member 1 (SERPINC1), were also identified. In conclusion, gene signatures identified from the genome-based assays could contribute to HCC stratification. WGCNA was able to identify significant groups of genes associated with cancer prognosis.
Keywords: hepatocellular carcinoma coexpression module microarray prognosis
Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block
Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 420-429 doi: 10.1007/s11684-016-0478-3
Keywords: CDKN2C acute promyelocytic leukemia cell cycle arrest differentiation
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 399-411 doi: 10.1007/s11684-010-0170-y
Keywords: hepatocellular carcinoma hepatitis B virus X protein β -catenin cell adhesion E-cadherin transcriptional
Na Chu, Donglin Wang, Houfeng Wang, Qinjun Liang, Jiali Chang, Yu Gao, Yong Jiang, Raymond Jianxiong Zeng
Engineering 2023, Volume 25, Issue 6, Pages 157-167 doi: 10.1016/j.eng.2021.09.015
The development of microbial electrosynthesis (MES) for renewable electricity-driven bioutilization of CO2 has recently attracted considerable interest due to its ability to synthesize chemicals with the transition towards a circular carbon economy. However, the increase of acetate production and the decrease of energy consumption of MES using an advanced reactor design have received less attention. In this study, the total acetate production rate using novel flow-electrode MES reactors ((16 ± 1) g·m−2·d−1) was double that using reactors without powder activated carbon (PAC) amendment ((8 ± 3) g·m−2·d−1). The flow-electrode MES reactors had a Coulombic efficiency of 43.5% ± 3.1%, an energy consumption of (0.020 ± 0.005) kW·h·g−1, and an energy efficiency of 18.7% ± 1.3% during acetate production. The flow-electrode with PAC amendment could decrease the net water flux and charge transfer resistance, while had little impact on the cell voltage, rheological behavior, and acetate adsorption. In the flow-electrode MES reactors, the expression of genes involving in energy production and conversion were increased, and the increase of acetate production was found correlated with the increased abundance of Acetobacterium. The Wood–Ljungdahl pathway (WLP) and reductive citric acid cycle (rTCA) were found to be the complete pathways responsible for carbon fixation. The concentrations of acetate in the stacked flow-electrode MES reached 7.0 g·L−1. This study presents a new approach for the construction of scalable MES reactors with high-performance chemical generation and CO2 utilization.
Keywords: CO2 utilization Biocathode Transcriptional analysis Microbial electrochemical technology
Title Author Date Type Operation
Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation
Journal Article
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu
Journal Article
Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block
Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang
Journal Article
Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
Journal Article